Posh head to the Hive to face the Bees of Barnet.
Peterborough United make the trip to the Hive this evening to face Barnet in the final group stage fixture of the Checkatrade Trophy (8pm).
With both sides unable to qualify for the next stage of the competition, changes are expected to be made by both managers as they take the opportunity to have a look at players who have yet to feature regularly in the starting line-up in league action.
Striker Lee Angol will start up front after making his comeback from a long-term injury in the 2-1 Emirates FA Cup success over Chesham United at the ABAX Stadium on Saturday.
McCann also confirmed that Ricardo Almeida Santos and Ryan Tafazolli will start at centre back with Jack Baldwin and Michael Bostwick not set to feature.
"It is a good opportunity to have a look at some of the players that have not featured as much as they perhaps would of liked in the first team so far this season and a good chance to give a few youngsters a taste of being involved in the first team squad.
"It is obviously a bit of a dead-rubber in terms of the competition, but we still want to win the game and that is our aim. Barnet may well make changes themselves but Martin Allen's sides always give you a real test.
"We might not play Barnet in the league, but we have had a number of pre-season friendly games down the years and I know what they are all about. They have some good players and in John Akinde, they have a strker in good form. He is a physical threat," McCann said.
Brad Inman won't feature in the squad, he is expected to face AFC Bournemouth for the reserve team next Wednesday at the Mick George Training Academy. Jermaine Anderson is a long-term injury absentee.
Barnet are still missing long-term absentees Michael Gash and James Pearson (both knee) while Gavin Hoyte is recovering from a hamstring injury.
Left-back Elliott Johnson returned in Saturday's Emirates FA Cup defeat to Shrewsbury Town. Sam Togwell (hernia) and Jamal Campbell-Ryce missed out though.
Admission for adults at the Hive is just £10 with concessions admitted for just £1.
Travelling Peterborough United fans will enter The Hive via turnstiles N1/N2 and can make use of the Jubilee Bar, situated in the West Stand. Food and drink will be available from there. Only the West Stand of the stadium is open.