Peterborough United head to the Weston Homes Community Stadium to face Colchester United on Saturday.
Darren Ferguson's men could go top of the fledgling Sky Bet League One table on Saturday if they can come away from Colchester United with all three points (3pm).
Leaders Fleetwood face a tough assignment against Leyton Orient as Posh look to build on their impressive start to the campaign.
'We went to Colchester on the back of an excellent start last season and were beaten 1-0. They played well on the day and it demonstrates that anyone can beat anyone at this level and we know that we have to be on our game if we are to get the right result.
'They are a youthful side and they spend a lot of money on their Academy. They do have one or two experienced members in the squad and we will know what to expect,' Ferguson said.
The Posh boss has received mixed news on the injury front with Nathaniel Mendez-Laing set for a spell on the sidelines after a scan revealed a thigh injury. He will definitely miss the fixture at Colchester.
However, Gabriel Zakuani, Kenny McEvoy and Kgosi Ntlhe are all expected to return from injury. Michael Bostwick and Jon Taylor remain 50-50. Jack Baldwin and Erhun Oztumer are definitely out. Marcus Maddison has been named in the squad after joining from Gateshead.
Jimmy Walker, the Posh Goalkeeping Coach, will be named on the substitutes bench following the departure of Joe Day to Newport County on a one-month loan deal.
'We have one or two players coming back and that does lead to one or two decisions that I have to make selection wise. I have one or two options both in personnel and in terms of the formation.
'The players did well last week at Bradford, but no two games are the same. Colchester will pose a different threat,' Ferguson said.
Posh have sold just over 650 tickets for the clash in advance. The game is not all-ticket but there is a price rise on the day.
Drey Wright and Josh Thompson could be pushing for a return to first-team duty for Colchester when Peterborough visit after featuring for the Under-21s at Crystal Palace on Tuesday.
Midfielder Wright is on the way back after sustaining a knee injury on the opening day of the season and defender Thompson suffered a hamstring strain during the warm-up at Charlton.